3D extrusion printing of high drug loading immediate release paracetamol tablets
نویسندگان
چکیده
منابع مشابه
Application of 3D Printing Technology in the Development of Novel Drug Delivery Systems
Three-dimensional printing (3DP) is a unique prototyping technology that has advanced over the past 35 years and has the great potential to revolutionize the field of drug delivery with its inherent advantages of customizability and the ability to fabricate complex solid dosage forms with high accuracy and precision. 3DP can fabricate solid dosage forms with variable densities and diffusivities...
متن کاملInfluence of process variables on release properties of paracetamol tablets.
A 2(3) factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times, t1, t50 and t90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization ...
متن کاملFabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing.
The aim of this work was to explore the feasibility of using fused deposition modelling (FDM) 3D printing (3DP) technology with hot melt extrusion (HME) and fluid bed coating to fabricate modified-release budesonide dosage forms. Budesonide was sucessfully loaded into polyvinyl alcohol filaments using HME. The filaments were engineered into capsule-shaped tablets (caplets) containing 9mg budeso...
متن کاملProcess Monitoring of Extrusion Based 3D Printing via Laser Scanning
Extrusion based 3D Printing (E3DP) is an Additive Manufacturing (AM) technique that extrudes thermoplastic polymer in order to build up components using a layerwise approach. Hereby, AM typically requires long production times in comparison to mass production processes such as Injection Molding. Failures during the AM process are often only noticed after build completion and frequently lead to ...
متن کاملPharmacokinetics and Pharmacodynamics of Gliclazide from Immediate and Modified Release Formulation Tablets in Rats
The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2018
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2018.01.024